Description

2-Azido-1-Pivaloyl-D-Erythro-Sphingosine is a key synthetic intermediate in advanced organic and medicinal chemistry. This compound is valued for its role as a versatile building block in the synthesis of complex bioactive molecules, particularly sphingolipid analogs and click chemistry probes. It is essential for researchers and manufacturers in pharmaceutical development, chemical biology, and life sciences who require high-purity intermediates for drug discovery and biochemical studies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel sphingolipid-based therapeutics and drug candidates.
• Chemical Biology Probe Synthesis: Used to create azide-functionalized probes for bioorthogonal "click chemistry" applications, enabling labeling and study of biological systems.
• Glycobiology Research: Serves as a precursor for synthesizing complex glycosphingolipids to study cell signaling, membrane structure, and recognition events.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by providing a modifiable scaffold for developing enzyme inhibitors or receptor modulators.
• Bioconjugation: The azido group facilitates conjugation to alkyne-bearing molecules, making it valuable for creating antibody-drug conjugates (ADCs) or diagnostic agents.
• Academic & Industrial R&D: A fundamental reagent for exploring new synthetic pathways and developing novel chemical entities in research laboratories.

Basic Information

Product Name	2-Azido-1-Pivaloyl-D-Erythro-Sphingosine
CAS No.	114275-41-1
Molecular Formula	C23H44N4O3
Molecular Weight	424.63 g/mol
Synonyms	D-erythro-2-Azido-1-pivaloylsphingosine; 2-Azido-1-pivaloyl-D-erythro-sphingosine; (2S,3R)-2-Azido-1-[(2,2-dimethylpropanoyl)oxy]-3-octadecanamidooctadec-4-ene; Pivaloyl-2-azido-D-erythro-sphingosine; 2-Azido-1-pivaloylsphingosine; N-[(1S,2R)-1-Azido-3-[(2,2-dimethylpropanoyl)oxy]-1-(octadec-9-en-1-yl)propan-2-yl]octadecanamide
EINECS	Contact for details

Quality Control

Our 2-Azido-1-Pivaloyl-D-Erythro-Sphingosine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.