Description

2'-o-Methyl-N2,N2-Dimethyl-Guanosine is a chemically modified nucleoside derivative, specifically a dimethylated guanosine analog. This compound is of significant value in oligonucleotide synthesis and pharmaceutical research, where it serves as a crucial building block for creating modified RNA sequences with enhanced stability and specific biological properties. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical developers working on antisense oligonucleotides, siRNA therapeutics, and other advanced nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of chemically modified RNA strands.
• Antisense Therapy Research: Used to incorporate stabilizing modifications into antisense oligonucleotides (ASOs) to improve nuclease resistance and pharmacokinetics.
• siRNA and miRNA Development: Employed in the design of small interfering RNA (siRNA) and microRNA (miRNA) analogs to enhance stability and reduce off-target effects.
• Structural Biology Studies: Utilized to probe RNA structure, function, and protein-RNA interactions by introducing specific modifications.
• Diagnostic Probe Development: Serves as a component in the creation of labeled probes for nucleic acid detection and diagnostic assays.
• Pharmaceutical Intermediate: Acts as a critical advanced intermediate in the development pathway of novel therapeutic nucleic acids.

Basic Information

Product Name	2'-o-Methyl-N2,N2-Dimethyl-Guanosine
CAS No.	113886-73-0
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	2'-O-Methyl-N2,N2-dimethylguanosine; N2,N2-Dimethyl-2'-O-methylguanosine; 1-(2-O-Methyl-β-D-ribofuranosyl)-N2,N2-dimethylguanine; 2'-OMe-N2,N2-dimethyl-G; 2'-O-Methyl-N2,N2-dimethylguanosine; Guanosine, 2'-O-methyl-N2,N2-dimethyl-; 2'-O-Methyl-N2,N2-dimethyl-Guanosine; N2,N2-Dimethyl-2'-O-methyl-Guanosine
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl-N2,N2-Dimethyl-Guanosine is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.