Description

Boc-Vgr-Amc CAS NO 113865-80-8 is a protected peptide derivative, specifically a Boc-protected tripeptide amide. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, protease substrates, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential construction of custom peptide chains in pharmaceutical research.
• Protease Substrate Development: Used in the design and synthesis of fluorogenic or chromogenic substrates to study enzyme kinetics and inhibitor screening.
• Bioconjugation & Probe Synthesis: Serves as a precursor for creating labeled peptides used in imaging, diagnostics, and target identification studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of peptide-based drug candidates.
• Biochemical Reagent Production: A raw material for manufacturers of high-purity biochemical reagents and assay kits.

Basic Information

Product Name	Boc-Vgr-Amc
CAS No.	113865-80-8
Molecular Formula	C24H36N6O7
Molecular Weight	520.58 g/mol
Synonyms	Boc-Val-Gly-Arg-AMC; Boc-Val-Gly-Arg-7-Amino-4-methylcoumarin; tert-Butyloxycarbonyl-Valyl-Glycyl-Arginine-AMC; N-α-(tert-Butoxycarbonyl)-L-valylglycyl-L-arginine 7-amido-4-methylcoumarin; VGR(AMC) substrate precursor; Fluorogenic peptide substrate intermediate; Boc-VGR-AMC; Boc-L-Val-Gly-L-Arg-AMC
EINECS	Contact for details

Quality Control

Our Boc-Vgr-Amc is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for reproducible research results. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and specifications can be aligned with client requirements for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is sensitive to light and moisture. Allow the container to reach room temperature before opening to minimize condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.