Description

2-[[(4S)-4-Carboxy-4-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]Butyl]Carbamoyl]Benzoic Acid is a high-purity, non-racemic chemical intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a sophisticated building block in the development of targeted therapeutics, particularly in oncology and metabolic disease research. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of novel drug candidates and complex molecular entities.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel folate antagonists and targeted chemotherapeutic agents.
• Biochemical Research: Used as a key precursor in enzymatic studies and the development of enzyme inhibitors for research purposes.
• Antifolate Drug Development: Serves as a core structural component in the research and development of next-generation antifolate drugs.
• Proteomics & Molecular Biology: Employed in the design and synthesis of specialized probes and ligands for studying biological pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Academic Research: Utilized in university and institutional laboratories for medicinal chemistry projects and drug discovery programs.

Basic Information

Product Name	2-[[(4S)-4-Carboxy-4-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]Butyl]Carbamoyl]Benzoic Acid
CAS No.	113857-87-7
Molecular Formula	C31H30N8O6
Molecular Weight	610.62 g/mol
Synonyms	(S)-2-((4-((4-((2,4-Diaminopteridin-6-yl)methylamino)benzamido)-4-carboxybutyl)carbamoyl)benzoic acid; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, 1-(2-carboxybenzoyl)-; Pteroic acid-L-glutamic acid derivative; 4-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-5-[(2-carboxybenzoyl)amino]-5-oxopentanoic acid; (4S)-4-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-4-carboxy-N-[(2-carboxyphenyl)carbonyl]butanamide
EINECS	Contact for details

Quality Control

Our 2-[[(4S)-4-Carboxy-4-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]Butyl]Carbamoyl]Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% (S-isomer)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.