Description

2-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]-6-Phosphono-Hexanoic Acid is a specialized, high-purity biochemical intermediate of significant interest in advanced pharmaceutical research and development. This compound matters as a key building block in the synthesis of novel folate analogs and enzyme inhibitors, offering researchers a critical tool for targeted therapeutic discovery. It is primarily needed by R&D laboratories and pharmaceutical manufacturers focused on developing next-generation oncology treatments, antimicrobial agents, and metabolic disorder therapies.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antifolate drugs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a high-purity reference standard and inhibitor in enzymatic studies, particularly those involving folate-dependent pathways.
• Oncology R&D: Investigated as a core structure for developing inhibitors of dihydrofolate reductase (DHFR) and other key enzymes in cancer cell proliferation.
• Antimicrobial Agent Development: Explored for creating compounds that interfere with bacterial folate synthesis, offering potential routes to new antibiotics.
• Metabolic Disorder Research: Applied in studies aiming to modulate purine and pyrimidine biosynthesis for therapeutic intervention.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	2-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]-6-Phosphono-Hexanoic Acid
CAS No.	113811-44-2
Molecular Formula	C20H26N8O6P
Molecular Weight	505.45 g/mol
Synonyms	6-Phosphono-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]hexanoic acid; PT523; Pteroic acid-6-amide, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-6-(phosphonooxy)-, (S)-; Glutamic acid analogue PT523; (S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]-6-phosphonohexanoic acid; Antifolate PT523; 6-Phosphonato-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]hexanoate
EINECS	Contact for details

Quality Control

Our 2-[[4-[(2,4-Diaminopteridin-6-Yl)Methylamino]Benzoyl]Amino]-6-Phosphono-Hexanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all relevant specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.