Description

S-(2-Chloroacetyl)Glutathione is a chemically modified derivative of the tripeptide glutathione, featuring a reactive chloroacetyl group. This compound is a critical intermediate and research chemical used in the synthesis of more complex molecules and for studying biochemical pathways. It is primarily utilized by pharmaceutical researchers, biochemists, and fine chemical manufacturers engaged in drug discovery and proteomics.

Application

• Biochemical Research: Used as a key intermediate in the study of enzyme inhibition, protein labeling, and glutathione-related metabolic pathways.
• Pharmaceutical Synthesis: Serves as a building block in the development of prodrugs and targeted therapeutic agents.
• Proteomics & Bioconjugation: Employed for the selective modification of proteins and peptides due to its reactive chloroacetyl moiety.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.
• Enzyme Activity Studies: Applied in assays to investigate the activity of glutathione S-transferases and other related enzymes.

Basic Information

Product Name	S-(2-Chloroacetyl)Glutathione
CAS No.	113668-38-5
Molecular Formula	C12H19ClN3O7S
Molecular Weight	384.81 g/mol
Synonyms	N-(N-L-γ-Glutamyl-L-cysteinyl)glycine S-(2-chloroacetyl); L-Glutathione, S-(2-chloroacetyl)-; S-Chloroacetylglytathione; 2-Chloroacetylglutathione; Chloroacetyl-GSH; Glutathione S-(2-chloroacetyl) ester; γ-Glu-Cys(ClAc)-Gly
EINECS	Contact for details

Quality Control

Our S-(2-Chloroacetyl)Glutathione is produced under controlled conditions to ensure high purity and batch-to-batch consistency. All products undergo rigorous quality testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.