Description

Fmoc-Gly-Osu CAS NO 113484-74-5 is a highly reactive, crystalline active ester derivative of Fmoc-protected glycine, specifically designed for peptide synthesis. This compound is a critical building block that enables efficient and high-yield coupling reactions under mild conditions, ensuring the integrity of sensitive amino acid sequences. It is an essential reagent for research institutions, pharmaceutical developers, and CROs engaged in solid-phase and solution-phase peptide synthesis for drug discovery and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key coupling reagent for the efficient incorporation of glycine residues into growing peptide chains on resin.
• Solution-Phase Peptide Synthesis: Used in classical peptide bond formation strategies where controlled, racemization-free coupling is required.
• Bioconjugation and Labeling: Facilitates the site-specific attachment of glycine-linked probes, tags, or other molecules to proteins, antibodies, or surfaces.
• Combinatorial Chemistry Library Production: Enables the rapid and automated synthesis of diverse peptide libraries for high-throughput screening.
• Research & Development of Peptide Therapeutics: Essential for the laboratory-scale synthesis of peptide drug candidates, including hormones, antimicrobial peptides, and enzyme inhibitors.
• Custom Peptide Service Providers: A staple raw material for companies offering bespoke peptide manufacturing services.

Basic Information

Product Name	Fmoc-Gly-Osu
CAS No.	113484-74-5
Molecular Formula	C₂₁H₂₀N₂O₆
Molecular Weight	396.40 g/mol
Synonyms	Fmoc-Glycine N-Hydroxysuccinimide Ester; N-(9-Fluorenylmethoxycarbonyl)glycine N-Hydroxysuccinimide Ester; Fmoc-Gly-OSu; Fmoc-Glycine Succinimidyl Ester; Fmoc-Gly-OH-OSu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine 2,5-dioxopyrrolidin-1-yl ester; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(2,5-dioxo-1-pyrrolidinyl) ester
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-Osu is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.