Description

Mal-Peg5-Ch2Ch2Mal is a heterobifunctional polyethylene glycol (PEG) derivative featuring maleimide and carboxylic acid termini, separated by a flexible PEG5 spacer. This compound is specifically engineered for the controlled, site-specific conjugation of biomolecules, such as antibodies and peptides, enabling the creation of stable, well-defined bioconjugates. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced materials development who require precise and reproducible crosslinking strategies.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical bifunctional linker for attaching cytotoxic payloads to antibodies via thiol-maleimide chemistry.
• PEGylation Reagent: Used to modify proteins, peptides, and nanoparticles to improve solubility, reduce immunogenicity, and prolong circulation half-life.
• Diagnostic Probe Conjugation: Facilitates the labeling of antibodies, enzymes, or other proteins with fluorescent dyes, enzymes, or other detection moieties.
• Surface Functionalization: Enables the covalent attachment of biomolecules to sensor surfaces, microarrays, and polymeric materials for biosensing and tissue engineering.
• Hydrogel Formation: Acts as a crosslinker in the synthesis of biocompatible hydrogels for drug delivery and 3D cell culture applications.
• Protein-Protein Conjugation: Allows for the site-specific coupling of different proteins to create multifunctional complexes or fusion mimics.

Basic Information

Product Name	Mal-Peg5-Ch2Ch2Mal
CAS No.	113387-03-4
Molecular Formula	C28H46N2O14
Molecular Weight	634.68 g/mol
Synonyms	Maleimide-PEG5-acid; 3,6,9,12,15-Pentaoxaheptacos-26-ene-1,27-dioic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; 1-[2-[2-[2-[2-[2-(2-Carboxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl] 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanedioate; MAL-PEG5-COOH; Maleimide-PEG5-Acid; Bifunctional PEG linker, Maleimide-Pentaethylene glycol-Acid.
EINECS	Contact for details

Quality Control

Our Mal-Peg5-Ch2Ch2Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.