Description

11-(4-(3-(Trifluoromethyl)Diazirinyl)Phenyl)Undecanoic Acid is a specialized bifunctional chemical probe featuring a photoreactive diazirine group and a carboxylic acid handle. This compound matters for researchers as it enables the covalent cross-linking and subsequent isolation of biomolecular targets, a critical technique in proteomics and drug discovery. It is primarily needed by pharmaceutical R&D teams, chemical biologists, and academic research institutions engaged in photoaffinity labeling, target identification, and activity-based protein profiling studies.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently tagging proteins and other biomolecules upon UV light activation to study ligand-receptor interactions.
• Chemical Proteomics: Used to create functionalized probes for activity-based protein profiling (ABPP) to identify enzyme targets and their functional states.
• Drug Discovery Target ID: Facilitates the identification of unknown protein targets for bioactive small molecules by enabling irreversible binding and pull-down assays.
• Bioconjugation & Linker Chemistry: The carboxylic acid group allows for conjugation to amines, alcohols, or other functional groups via amide or ester bonds, serving as a versatile linker.
• Material Surface Functionalization: Can be used to introduce photoreactive groups onto surfaces or polymers for creating bioactive interfaces.
• Metabolic Pathway Analysis: Employed in the synthesis of probes to trace and capture metabolites or intermediates within living systems.

Basic Information

Product Name	11-(4-(3-(Trifluoromethyl)Diazirinyl)Phenyl)Undecanoic Acid
CAS No.	113274-80-9
Molecular Formula	C20H25F3N2O2
Molecular Weight	382.42 g/mol
Synonyms	3-(Trifluoromethyl)-3H-diazirin-3-yl Benzenepropanoic Acid, 11-[4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenyl]-; 11-[4-(3-(Trifluoromethyl)diazirin-3-yl)phenyl]undecanoic acid; TPD-Undecanoic Acid; Photoaffinity Labeling Probe; Diazirine-C11-COOH; (3-(Trifluoromethyl)diazirin-3-yl)phenyl Undecanoic Acid Derivative; Carboxylic Acid Functionalized Diazirine
EINECS	Contact for details

Quality Control

Our 11-(4-(3-(Trifluoromethyl)Diazirinyl)Phenyl)Undecanoic Acid is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive and hygroscopic; therefore, containers should be allowed to equilibrate to room temperature before opening to minimize moisture ingress. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.