Description

(S)-n-(5-Amino-1-Carboxypentyl)Iminodiacetic Acid Hydrate is a high-purity, chiral chelating agent and a key synthetic intermediate in the production of advanced pharmaceuticals and diagnostic agents. Its primary value lies in its role as a precursor for sophisticated contrast media used in magnetic resonance imaging (MRI), where its specific stereochemistry is critical for biological compatibility and efficacy. This compound is essential for research institutions and manufacturers in the pharmaceutical, biotechnology, and medical diagnostics sectors developing next-generation imaging technologies and targeted therapeutics.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of gadolinium-based MRI contrast agents (e.g., Gadobutrol, Gadoteridol).
• Diagnostic Agent Synthesis: Building block for novel macrocyclic chelators used in molecular imaging and radiopharmaceuticals.
• Bioconjugation Chemistry: Used to create bifunctional chelators for attaching metal isotopes to antibodies, peptides, or other targeting molecules.
• Research & Development: Valuable tool in academic and industrial R&D for studying metal-ligand interactions and developing new chelation therapies.
• High-Purity Chemical Reagent: Serves as a standard or reagent in analytical chemistry and quality control laboratories.

Basic Information

Product Name	(S)-n-(5-Amino-1-Carboxypentyl)Iminodiacetic Acid Hydrate
CAS No.	113231-05-3
Molecular Formula	C10H19N3O6 • xH2O
Molecular Weight	277.28 g/mol (Anhydrous basis)
Synonyms	(S)-DO3A-tris(t-butyl ester) precursor; (S)-2-[Bis(carboxymethyl)amino]-5-[(carboxymethyl)amino]pentanoic acid hydrate; H5DO3A hydrate; (S)-1,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane precursor; Gadolinium chelator intermediate; (S)-α-(Carboxymethyl)-DOTA tris(t-butyl ester) hydrolysis product; (S)-N-(5-Amino-1-carboxypentyl)iminodiacetic acid
EINECS	Contact for details

Quality Control

Our (S)-n-(5-Amino-1-Carboxypentyl)Iminodiacetic Acid Hydrate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific customer or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 5.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.