Description

P1,P4-Di(Adenosine-5') Tetraphosphate, Periodate Oxidized Sodium Salt is a chemically modified nucleotide derivative, specifically a periodate-oxidized form of the dinucleotide polyphosphate Ap4A. This compound matters as a critical biochemical tool and potential precursor in nucleotide research, offering a reactive aldehyde group for conjugation and cross-linking studies. It is primarily needed by researchers and manufacturers in the fields of biochemistry, molecular biology, and pharmaceutical development for investigating nucleotide metabolism, enzyme mechanisms, and developing novel diagnostic or therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of dinucleotide polyphosphate metabolism and related kinases or synthetases.
• Cross-linking Agent: The periodate-oxidized aldehyde group enables conjugation to proteins, antibodies, or other biomolecules for affinity labeling or probe development.
• Nucleotide Analog Synthesis: Serves as a key intermediate or precursor in the chemical synthesis of modified nucleotides and dinucleotides for structure-activity relationship (SAR) studies.
• Cell Signaling Studies: Investigated for its role and effects as a dinucleotide signaling molecule (alarmone) in cellular stress responses.
• Diagnostic Assay Development: Potential use in developing enzymatic or binding assays to detect specific enzyme activities or biomarkers.
• Pharmaceutical R&D: Evaluated for its biological activity and potential as a lead compound in drug discovery programs targeting purinergic signaling pathways.

Basic Information

Product Name	P1,P4-Di(Adenosine-5') Tetraphosphate, Periodate Oxidized Sodium Salt
CAS No.	112968-03-3
Molecular Formula	C20H23N10O23P4Nax (x varies)
Molecular Weight	Contact for details
Synonyms	Periodate-oxidized Ap4A sodium salt; Oxidized Diadenosine tetraphosphate; P1,P4-Di(adenosine-5')-tetraphosphate, periodate-oxidized; Ap4A dialdehyde; Diadenosine 5',5'''-P1,P4-tetraphosphate periodate-oxidized sodium salt; Adenosine tetraphosphate derivative, oxidized; Dinucleotide polyphosphate aldehyde
EINECS	Contact for details

Quality Control

Our P1,P4-Di(Adenosine-5') Tetraphosphate, Periodate Oxidized Sodium Salt is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic identification (UV, NMR). Certificates of Analysis (COA) detailing the specific results for each batch are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.