Description

2-Desamino-2-Methyl-5,8-Dideazaisofolic Acid is a high-purity, non-classical folate analog designed for advanced pharmaceutical research and development. This compound is a critical intermediate and reference standard in the synthesis of novel chemotherapeutic agents targeting folate-dependent enzymes. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, specifically for developing inhibitors of thymidylate synthase and other key metabolic pathways. The material is supplied to exacting standards to ensure reliable and reproducible results in sensitive biochemical assays.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antifolate and anticancer drug candidates.
• Biochemical Research: Used as a reference standard and inhibitor in enzymatic studies of thymidylate synthase and dihydrofolate reductase.
• Oncology Drug Discovery: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Academic Research: Employed in universities and research institutes for investigating folate metabolism and enzyme kinetics.
• Reference Material: Provides a high-purity standard for analytical method development and validation (HPLC, LC-MS).

Basic Information

Product Name	2-Desamino-2-Methyl-5,8-Dideazaisofolic Acid
CAS No.	112887-79-3
Molecular Formula	C20H22N4O5
Molecular Weight	398.42 g/mol
Synonyms	2-Desamino-2-methyl-5,8-dideazafolic acid; 2-Methyl-5,8-dideazaisofolic acid; 5,8-Dideaza-2-methylisofolic acid; NSC 354646; Isofolic acid analog; Non-classical folate antagonist; Thymidylate synthase inhibitor intermediate
EINECS	Contact for details

Quality Control

Every batch of 2-Desamino-2-Methyl-5,8-Dideazaisofolic Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), residual solvents, and related substances is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.