Description

Raltitrexed is a potent and specific thymidylate synthase inhibitor, functioning as an antimetabolite chemotherapeutic agent. Its primary value lies in its targeted mechanism of action, which disrupts DNA synthesis in rapidly dividing cells. This compound is essential for pharmaceutical research and development, particularly in the field of oncology. It serves as a critical active pharmaceutical ingredient (API) and reference standard for the development and quality control of cancer therapeutics.

Application

• Pharmaceutical API: Serves as the active pharmaceutical ingredient in the formulation of injectable chemotherapeutic drugs.
• Oncology Research: Used as a key biochemical tool in cancer research to study thymidylate synthase inhibition and mechanisms of antimetabolite action.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, and other methods for quality control and assay development.
• Drug Development: A critical compound for preclinical and clinical studies aimed at evaluating efficacy and safety profiles in various cancer models.
• Biochemical Assays: Utilized in enzymatic assays to screen for novel inhibitors or to study folate metabolism pathways.

Basic Information

Product Name	Raltitrexed
CAS No.	112887-68-0
Molecular Formula	C21H22N4O6S
Molecular Weight	458.49 g/mol
Synonyms	ZD1694; Tomudex; N-[5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid; ICI D1694; 6-[[(3,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thenoyl-L-glutamic acid; Raltitrexedum; Raltitrexed hydrate
EINECS	Contact for details

Quality Control

Our Raltitrexed is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific pharmacopeial requirements (e.g., USP, EP, JP).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.