Description

(4''R)-22-o-(3-Amino-3-C-Methyl-2,3,6-Trideoxy-α-L-Arabino-Hexopyranosyl)-10-Dechloro-56-Methylvancomycin is a structurally modified glycopeptide antibiotic derivative, representing a key intermediate in advanced pharmaceutical research. This compound is critical for the development of next-generation antimicrobial agents targeting resistant bacterial strains. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and fine chemical manufacturers focused on novel antibiotic synthesis and mechanism-of-action studies.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel semi-synthetic glycopeptide antibiotics.
• Antimicrobial Research: Used in biochemical and microbiological studies to investigate structure-activity relationships (SAR) against Gram-positive bacteria.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in lead optimization programs to develop antibiotics with improved efficacy and reduced toxicity profiles.
• Mechanistic Studies: Utilized to study the inhibition of bacterial cell wall biosynthesis and the binding to D-Ala-D-Ala peptide termini.

Basic Information

Product Name	(4''R)-22-o-(3-Amino-3-C-Methyl-2,3,6-Trideoxy-α-L-Arabino-Hexopyranosyl)-10-Dechloro-56-Methylvancomycin
CAS No.	112848-46-1
Molecular Formula	C66H77Cl2N9O24
Molecular Weight	1444.26 g/mol
Synonyms	10-Dechloro-56-methylvancomycin 22-O-(3-amino-3-C-methyl-2,3,6-trideoxy-α-L-arabino-hexopyranoside); (4''R)-22-O-(3-Amino-3-C-methyl-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)-10-dechloro-56-methylvancomycin; Methylvancomycin derivative; Antibiotic intermediate; Glycopeptide derivative; Vancomycin analog; Research antibiotic compound
EINECS	Contact for details

Quality Control

Our (4''R)-22-o-(3-Amino-3-C-Methyl-2,3,6-Trideoxy-α-L-Arabino-Hexopyranosyl)-10-Dechloro-56-Methylvancomycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.