Description

Topsentin CAS NO 112515-43-2 is a bis-indole alkaloid marine natural product known for its unique structural framework and significant biological activity. This compound serves as a valuable biochemical tool and a promising lead structure in pharmaceutical research, particularly for its potent anti-inflammatory and kinase inhibitory properties. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in drug discovery programs targeting cancer and inflammatory diseases.

Application

• Biochemical Research: Used as a reference standard and a potent inhibitor in enzymatic and cellular assays to study specific kinase pathways.
• Pharmaceutical R&D: Serves as a key lead compound for the synthesis of novel analogs in anti-cancer and anti-inflammatory drug discovery projects.
• Mechanistic Studies: Employed to investigate cellular signaling mechanisms related to inflammation and proliferation.
• Academic Research: Utilized in university and institutional labs for fundamental studies on marine natural product chemistry and bioactivity.
• High-Throughput Screening (HTS): Acts as a bioactive control or a hit compound in screening libraries for new therapeutic targets.

Basic Information

Item	Detail
Product Name	Topsentin
CAS No.	112515-43-2
Molecular Formula	C22H14Br2N4O2
Molecular Weight	534.18 g/mol
Synonyms	Topsentin; 6'-Bromo-3'-demethyl-3'-N-methyltopsentin; 6'-Bromo-3'-demethyl-N1-methyltopsentin; 6-Bromo-3-demethyl-3-N-methyltopsentin; Bis(indolyl)imidazole Alkaloid; Marine Alkaloid Topsentin; Topsentin Alkaloid
EINECS	Contact for details

Quality Control

Our Topsentin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are accompanied by comprehensive analytical data, including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.