Description

5,8-Epoxy-13-Cis Retinoic Acid is a synthetic retinoid derivative, a class of compounds structurally related to vitamin A. This compound is valued for its specific biological activity and serves as a crucial advanced pharmaceutical intermediate in the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in dermatology, oncology, and metabolic disease research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel retinoid-based drugs targeting skin disorders and cancers.
• Biochemical Research: Used as a reference standard and active probe in studies of retinoid receptor (RAR/RXR) signaling pathways.
• Dermatological R&D: Investigated for its potential efficacy in the development of treatments for acne, psoriasis, and photoaging.
• Oncology Research: Employed in preclinical studies for its effects on cell differentiation, proliferation, and apoptosis in various cancer cell lines.
• Metabolic Disease Studies: Utilized in research exploring the role of retinoids in metabolic regulation and related disorders.

Basic Information

Product Name	5,8-Epoxy-13-Cis Retinoic Acid
CAS No.	112018-12-9
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.43 g/mol
Synonyms	13-cis-5,8-Epoxyretinoic Acid; 5,8-Epoxy-13-cis-Retinoic Acid; 13-cis-5,8-Epoxyretinoate; (2E,4E,6E,8E)-9-(3,6-Epoxy-3,6-dihydro-2H-pyran-2-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic Acid; Retinoid Derivative 112018-12-9; 13-cis-5,8-Epoxy Retinoic Acid; 5,8-Epoxy Tretinoin Analog
EINECS	Contact for details

Quality Control

Our 5,8-Epoxy-13-Cis Retinoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.