Description

11-Fluorodihydrotestosterone is a potent synthetic androgen receptor agonist and a fluorinated derivative of the endogenous hormone dihydrotestosterone (DHT). This compound is of significant value in biochemical and pharmaceutical research due to its enhanced metabolic stability and binding affinity imparted by the fluorine substitution. It is primarily utilized by research institutions and pharmaceutical developers focused on endocrinology, steroid receptor biology, and the development of novel therapeutic agents for androgen-related conditions.

Application

• Biochemical Research: Used as a high-affinity ligand in studies of androgen receptor (AR) structure, function, and signaling pathways.
• Pharmaceutical R&D: Serves as a key reference standard and intermediate in the discovery and development of selective androgen receptor modulators (SARMs) and other steroidal therapeutics.
• Endocrinology Studies: Employed to investigate the physiological and pathological roles of androgens in model systems.
• Metabolic Stability Assays: The fluorine atom at the 11-position makes it a valuable tool for studying the impact of halogenation on the pharmacokinetic properties of steroid hormones.
• Competitive Binding Assays: Utilized as a radiolabeled or cold competitor in receptor binding experiments to determine affinity constants.

Basic Information

Product Name	11-Fluorodihydrotestosterone
CAS No.	111984-12-4
Molecular Formula	C19H29FO2
Molecular Weight	308.43 g/mol
Synonyms	11β-Fluoro-5α-dihydrotestosterone; 11β-Fluoro-17β-hydroxy-5α-androstan-3-one; 11-Fluoro-5α-DHT; 11-F-DHT; 11β-Fluoroandrostanolone; Fluoxydiolone (related); 11-Fluorostanolone
EINECS	Contact for details

Quality Control

Our 11-Fluorodihydrotestosterone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.