Description

Nbd-Glucocerebroside is a fluorescently labeled derivative of glucocerebroside, a key glycosphingolipid, designed for advanced biochemical research and diagnostic applications. This compound is essential for studying lipid metabolism, lysosomal function, and the molecular mechanisms underlying Gaucher disease. It serves as a critical tool for researchers and developers in the fields of pharmaceutical R&D, clinical diagnostics, and life science research, enabling precise tracking and analysis of cellular processes.

Application

• Biochemical Research: As a fluorescent probe for studying glucocerebroside metabolism, lysosomal storage disorders, and sphingolipid biology.
• Diagnostic Assay Development: Used in the formulation of enzyme activity assays for screening and diagnosing Gaucher disease.
• Pharmaceutical R&D: A key substrate in high-throughput screening (HTS) platforms for identifying and evaluating potential therapeutic compounds targeting glucocerebrosidase.
• Cell Biology Studies: Enables visualization and tracking of lipid transport and accumulation within cellular models using fluorescence microscopy.
• Enzyme Kinetics: Serves as a specific substrate for kinetic studies of recombinant or native glucocerebrosidase enzyme.
• Quality Control in Biologics: Used in potency assays for enzyme replacement therapies (ERTs) related to lysosomal storage diseases.

Basic Information

Product Name	Nbd-Glucocerebroside
CAS No.	111957-43-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	6-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl-Glucosylceramide; NBD-C6-Glucocerebroside; NBD-labeled Glucosylceramide; Fluorescent Glucocerebroside; NBD-GlcCer; 4-Nitro-2,1,3-benzoxadiazol-7-yl Glucocerebroside Derivative
EINECS	Contact for details

Quality Control

Our Nbd-Glucocerebroside is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, fluorescence spectroscopy, and identity confirmation (IR/NMR). Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is light-sensitive and easily oxidized; allow it to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Fluorescence Properties	Ex/Em ~465/535 nm in suitable solvent
Solubility	Soluble in chloroform, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.