Description

Hsv-Tk Substrate CAS NO 111687-37-7 is a specialized biochemical reagent designed for use in gene therapy and molecular biology research. This compound serves as a critical substrate for the Herpes Simplex Virus Thymidine Kinase (HSV-TK) enzyme, enabling selective cell ablation and targeted therapeutic applications. It is essential for researchers and developers in the fields of oncolytic virotherapy, suicide gene therapy, and advanced cell culture models, providing a reliable tool for precise genetic manipulation and cytotoxicity studies.

Application

• Suicide Gene Therapy Systems: Used as the activating prodrug in HSV-TK/ganciclovir (GCV) systems for targeted cancer cell elimination.
• Oncolytic Virotherapy Research: A key component in studies evaluating the efficacy and safety of engineered viruses for tumor treatment.
• Cell Line Engineering and Safety Switches: Employed in the development of genetically modified cell lines with built-in contingency mechanisms for controlled ablation.
• Molecular Biology & Biochemistry: Acts as a specific substrate in enzymatic assays to study HSV-TK kinetics and inhibitor screening.
• Preclinical Drug Development: Utilized in animal models to validate gene therapy vectors and assess biodistribution and therapeutic windows.
• Stem Cell Research: Facilitates the development of safer stem cell therapies by enabling the removal of undifferentiated or mis-differentiated cells.

Basic Information

Product Name	Hsv-Tk Substrate
CAS No.	111687-37-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ganciclovir; 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine; DHPG; BW 759; Cytovene; Cymevene; 2'-Nor-2'-deoxyguanosine; NSC 613795; BIOLF-62
EINECS	Contact for details

Quality Control

Our Hsv-Tk Substrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation (IR/NMR), and stringent limits for impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Biological Activity	Conforms to reference standard in enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.