Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Glutaryl) (Sodium Salt) is a synthetic, anionic phospholipid derivative, widely recognized as a key functional lipid in advanced formulation science. Its primary value lies in its unique chemical structure, which combines the fusogenic properties of dioleoyl phosphatidylethanolamine (DOPE) with a glutaryl linker, enabling versatile conjugation and enhanced functionality in complex delivery systems. This high-purity lipid is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing sophisticated liposomal drug delivery vehicles, lipid nanoparticles (LNPs) for nucleic acid therapeutics, and other advanced biomaterial applications.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical functional excipient for constructing stable and efficient LNPs used in mRNA, siRNA, and gene therapy delivery systems.
• Stabilized Liposome Production: Used to impart negative surface charge and improve the stability, circulation time, and targeting capabilities of therapeutic liposomes.
• Bioconjugation & Ligand Attachment: The reactive glutaryl group serves as a convenient linker for covalently attaching targeting ligands (e.g., antibodies, peptides) or PEG chains to lipid bilayers.
• Membrane Fusion Studies: Employed in biophysical research to study membrane dynamics, fusion mechanisms, and model membrane systems due to its non-bilayer forming propensity.
• Diagnostic Reagent Development: A component in the formulation of contrast agents or diagnostic probes for imaging applications.
• Cosmetic & Dermal Delivery Systems: Used in high-end cosmetic formulations to create nanocarriers for the enhanced skin penetration of active ingredients.

Basic Information

Item	Detail
Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Glutaryl) (Sodium Salt)
CAS No.	111516-02-0
Molecular Formula	C47H85NNaO11P
Molecular Weight	918.14 g/mol
Synonyms	18:1 DOPE-Glutaryl (Na Salt); DOPE-Glutaryl Sodium Salt; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-glutaryl (sodium salt); N-Glutaryl-DOPE (Sodium Salt); DOGS analogue; Anionic DOPE derivative; N-(Glutaryl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine sodium salt; Phospholipid-PE(18:1/18:1)-glutaryl-Na
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Glutaryl) (Sodium Salt) is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive pharmaceutical and research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and related substances, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maintain stability and prevent oxidation and hydrolysis. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Complies
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.