Description

1,2-Dioctanoylthiophosphatidylcholine is a synthetic, sulfur-containing phospholipid analog, specifically a thiophosphatidylcholine derivative. This compound is of significant interest in advanced research and development due to its unique chemical structure, which modifies the phosphate ester linkage, offering distinct properties compared to native phospholipids. It is primarily utilized by researchers and formulators in the pharmaceutical and biotechnology sectors. The material is supplied with a CAS number of 111466-75-2.

Application

• Lipid Nanoparticle (LNP) Research: As a structural component or functional excipient in the development of novel lipid-based delivery systems for nucleic acids (mRNA, siRNA).
• Membrane Biochemistry Studies: Used as a probe or model compound to investigate membrane dynamics, protein-lipid interactions, and the role of phospholipid headgroup modifications.
• Drug Delivery Vehicle Development: Incorporated into liposomal or micellar formulations to alter stability, release profiles, and cellular uptake mechanisms of encapsulated active ingredients.
• Biomimetic Material Synthesis: Serves as a building block for creating advanced materials that mimic biological membrane properties for sensors or diagnostic devices.
• Enzyme Substrate Studies: Acts as a specialized substrate for phospholipase enzymes to study inhibition kinetics and catalytic mechanisms.

Basic Information

Product Name	1,2-Dioctanoylthiophosphatidylcholine
CAS No.	111466-75-2
Molecular Formula	C26H52NO6PS
Molecular Weight	537.71 g/mol
Synonyms	1,2-Di-O-octanoyl-sn-glycero-3-thiophosphocholine; Thiophosphatidylcholine, dioctanoyl; Dioctanoylthiophosphatidylcholine; 1,2-Di-O-octanoyl-3-O-(thiophospho)-sn-glycerolcholine; sn-Glycero-3-phosphothiocholine, 1,2-dioctanoate; Phosphatidylthiocholine (C8:0); 3-sn-Phosphatidylthiocholine, 1,2-dioctanoyl
EINECS	Contact for details

Quality Control

Our 1,2-Dioctanoylthiophosphatidylcholine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency suitable for research applications. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as NMR, HPLC, and mass spectrometry. For specific purity grades or custom specifications, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed container to reach room temperature before opening to prevent condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0 %
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.