Description

N,n-Dibenzyloxycarbonyl-Lysine Anhydride is a protected amino acid derivative, specifically a lysine derivative with orthogonal protecting groups. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering controlled reactivity for sequential deprotection strategies. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of lysine residues, enabling the synthesis of peptides with specific side-chain functionalities.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex peptide fragments and small proteins where selective deprotection is required.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Linker Chemistry: The reactive anhydride and protected amine groups make it valuable for creating custom linkers and modifying biomolecules.
• Academic and Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and the creation of novel chemical entities.
• Production of Specialty Peptides: Used in manufacturing custom peptides for research, diagnostic kits, and high-value biochemical tools.

Basic Information

Product Name	N,n-Dibenzyloxycarbonyl-Lysine Anhydride
CAS No.	111142-54-2
Molecular Formula	C22H24N2O7
Molecular Weight	428.44 g/mol
Synonyms	Nε,Nα-Bis(benzyloxycarbonyl)-L-lysine Anhydride; Nα,Nε-Bis(Cbz)-L-lysine Anhydride; (S)-2,6-Bis((benzyloxy)carbonylamino)hexanoic Anhydride; Z-Lys(Z)-Anhydride; Lys(Z2)-Anhydride; N,N-Di-Cbz-L-lysine Anhydride; Boc-Lys(Z)-OH Anhydride (related); Lysine Nα,Nε-bis(benzyloxycarbonyl) Anhydride
EINECS	Contact for details

Quality Control

Our N,n-Dibenzyloxycarbonyl-Lysine Anhydride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent hydrolysis of the anhydride functionality. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.