Description

5,6,7,8-Tetrahydro-8-Deazahomofolic Acid is a high-purity biochemical intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block in the synthesis of novel therapeutic agents, particularly in the field of oncology and metabolic disease research. It is essential for research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of next-generation drug candidates and diagnostic tools.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antifolate and antimetabolite drug candidates for oncology applications.
• Biochemical Research: Used as a reference standard and active component in enzymatic studies targeting dihydrofolate reductase (DHFR) and related pathways.
• Anticancer Agent Development: Serves as a core scaffold for developing targeted therapies aimed at disrupting folate metabolism in cancer cells.
• Academic & Contract Research: Employed in university and CRO laboratories for mechanistic studies and high-throughput screening assays.
• Diagnostic Reagent Synthesis: Utilized in the production of specialized reagents for clinical diagnostics and research kits.

Basic Information

Product Name	5,6,7,8-Tetrahydro-8-Deazahomofolic Acid
CAS No.	111113-75-8
Molecular Formula	C20H23N7O5
Molecular Weight	441.44 g/mol
Synonyms	8-Deaza-5,6,7,8-tetrahydrohomofolic acid; THF-DHA; NSC 339531; 5,6,7,8-Tetrahydro-8-deazahomopteroylglutamic acid; 8-Deazaaminopterin analog; Homofolate analog; Tetrahydrodeazahomofolate
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydro-8-Deazahomofolic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.