Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Hexanoylamine) is a synthetic, amine-functionalized phospholipid widely used as a critical functional excipient in advanced drug delivery systems. Its primary value lies in its ability to facilitate targeted delivery and enhance the stability of complex formulations, particularly lipid nanoparticles. This high-purity lipid is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors developing next-generation therapeutics and diagnostics.

Application

• Lipid Nanoparticle (LNP) Formulation: A key cationic/ionizable lipid component for the encapsulation and delivery of nucleic acids (mRNA, siRNA, pDNA) in vaccines and gene therapies.
• Liposome & Niosome Preparation: Used to create functionalized vesicles for targeted drug delivery, improving cellular uptake and payload release.
• Surface Modification & Conjugation: The reactive primary amine group enables covalent attachment of targeting ligands (e.g., antibodies, peptides) or PEG chains for stealth properties.
• Biomimetic Membrane Research: Serves as a model phospholipid in biophysical studies to investigate membrane fusion, protein-lipid interactions, and cellular uptake mechanisms.
• Diagnostic Reagent Development: Employed in the fabrication of biosensors and diagnostic assays where stable, functionalized lipid layers are required.
• Cosmetic & Dermal Delivery Systems: Incorporated into nanocarriers for the enhanced penetration and stabilization of active ingredients in cosmetic formulations.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Hexanoylamine)
CAS No.	110796-31-1
Molecular Formula	C47H88NO8P
Molecular Weight	826.18 g/mol
Synonyms	DOPE-N-Hexanoylamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(hexanoylamine); N-Hexanoyl-DOPE; DOPE-C6; Amine-PEG-lipid analog; C6-DOPE; N-(6-Oxohexanoyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; Functionalized DOPE
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Hexanoylamine) is manufactured under strict quality systems suitable for pharmaceutical R&D and GMP-grade applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurities. We ensure compliance with relevant ICH guidelines and support customer audits for supply chain transparency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residue (GC)	Meets ICH limits
Water Content (KF)	≤ 1.0%
Phase Transition Temperature (DSC)	Reported

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.