Description

Noribogaine Hcl is a hydrochloride salt form of the primary metabolite of the psychoactive indole alkaloid ibogaine. This compound is of significant interest in advanced pharmaceutical research and development due to its distinct pharmacological profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, addiction therapy studies, and the development of novel central nervous system (CNS) agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for analytical method development, validation, and quality control in drug discovery and manufacturing.
• Neuroscience Research: Used in preclinical studies to investigate mechanisms related to neuroplasticity, addiction pathways, and potential therapeutic interventions for substance use disorders.
• Metabolite Studies: Essential for pharmacokinetic and metabolic profiling research of ibogaine and related compounds in both in vitro and in vivo models.
• Biochemical Assay Development: Employed as a key reagent in the development of high-throughput screening (HTS) assays and receptor binding studies targeting specific CNS receptors.
• Active Pharmaceutical Ingredient (API) Intermediate: Functions as a high-purity building block in the synthetic pathways for developing novel therapeutic candidates.

Basic Information

Product Name	Noribogaine Hcl
CAS No.	110514-35-7
Molecular Formula	C₁₂H₁₆N₂O•HCl
Molecular Weight	232.73 g/mol (free base: 196.27 g/mol)
Synonyms	12-Hydroxyibogamine hydrochloride; Noribogaine hydrochloride; 10-Hydroxyibogamine HCl; Ibogamine-12-ol hydrochloride; 12-Hydroxyibogamine HCl; Noribogaine HCl; 3-[(2R,3aS,4S,9bS)-4-Ethyl-3a,4,5,7-tetrahydro-3H-pyrano[4,3-b]indol-2-yl]propan-1-ol hydrochloride
EINECS	Contact for details

Quality Control

Our Noribogaine Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.