Description

1-Methyl-5-(2-Deoxy-2-Fluoroarabinofuranosyl)Uracil is a fluorinated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel antiviral and anticancer agents, leveraging its modified sugar moiety to enhance biological activity and metabolic stability. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antiviral and anticancer prodrugs.
• Antiviral Research: Used in the development of nucleoside analogs targeting viral polymerases.
• Oncology Research: Investigated as a precursor for chemotherapeutic agents that inhibit DNA synthesis in rapidly dividing cells.
• Biochemical Studies: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism.
• Process Development: Serves as a reference standard and starting material for scaling up API (Active Pharmaceutical Ingredient) manufacturing processes.
• Labeled Compound Synthesis: A precursor for creating isotopically labeled versions for pharmacokinetic and metabolic tracing studies.

Basic Information

Product Name	1-Methyl-5-(2-Deoxy-2-Fluoroarabinofuranosyl)Uracil
CAS No.	110419-25-5
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	2'-Fluoro-2'-deoxy-1-methylarabinofuranosyluracil; 1-Methyl-5-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil; 2'-F-ara-1-MeU; 2'-Fluoro-1-methylarabinofuranosyluracil; 1-Methyl-5-(2-fluoro-2-deoxy-β-D-arabinofuranosyl)uracil; FMAU (ambiguous, context-specific); 2'-Deoxy-2'-fluoro-1-methylarabinofuranosyluracil
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(2-Deoxy-2-Fluoroarabinofuranosyl)Uracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.