Description

20R-Camptothecin is a high-purity, stereochemically defined derivative of the potent natural product camptothecin, a key scaffold in oncology research. This compound is critical for the development and study of novel topoisomerase I inhibitors, which are essential in anticancer drug discovery pipelines. It serves as a vital reference standard and advanced pharmaceutical intermediate for research institutions, biotechnology firms, and pharmaceutical manufacturers engaged in targeted cancer therapy development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of advanced, more soluble camptothecin analogs like topotecan and irinotecan.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) of anticancer drug substances and products.
• Biochemical Research: Employed in vitro and in vivo studies to investigate the mechanism of action of topoisomerase I inhibition and apoptosis induction.
• Drug Discovery & Development: A crucial starting material for medicinal chemistry programs aimed at creating new chemotherapeutic agents with improved efficacy and reduced side effects.
• Academic Research: Utilized in university and institutional labs for fundamental studies on cell cycle dynamics, DNA damage, and cancer biology.

Basic Information

Product Name	20R-Camptothecin
CAS No.	110351-92-3
Molecular Formula	C20H16N2O4
Molecular Weight	348.35 g/mol
Synonyms	(20R)-Camptothecin; 20(R)-Camptothecin; Camptothecin, (20R)-; (R)-Camptothecin; 20R-CPT; CPT, 20R-; 20R-Hydroxycamptothecin (related); (20R)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
EINECS	Contact for details

Quality Control

Our 20R-Camptothecin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (20R-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.