Description

2-((3-Aminopropyl)Thio)Adenosine 5'-Diphosphate is a chemically modified nucleotide analog that serves as a critical biochemical tool. This compound is valued for its role as a potent and selective antagonist of P2Y1 purinergic receptors, enabling advanced research in cellular signaling pathways. It is primarily utilized by researchers and developers in the fields of pharmacology, neuroscience, and cardiovascular research for studying platelet aggregation, neurotransmission, and other receptor-mediated processes.

Application

• Biochemical Research: As a selective P2Y1 receptor antagonist for studying purinergic signaling in vitro and in vivo.
• Cardiovascular Studies: Investigation of platelet aggregation mechanisms and the development of novel anti-thrombotic agents.
• Neuroscience Research: Exploration of ATP-mediated neurotransmission, synaptic plasticity, and glial cell communication.
• Drug Discovery: A key reference standard and pharmacological tool in high-throughput screening (HTS) assays for identifying new receptor modulators.
• Enzymology: Used in studies of nucleotide-metabolizing enzymes due to its modified, hydrolysis-resistant structure.
• Cell Biology: Probing the role of extracellular nucleotides in cell proliferation, apoptosis, and inflammatory responses.

Basic Information

Product Name	2-((3-Aminopropyl)Thio)Adenosine 5'-Diphosphate
CAS No.	110224-45-8
Molecular Formula	C13H21N6O10P2S
Molecular Weight	515.35 g/mol
Synonyms	2-[(3-Aminopropyl)thio]adenosine 5'-(trihydrogen diphosphate); 2-(3-Aminopropylthio)-ATP; APS-ATP; AR-C69931MX (precursor form); P2Y1 receptor antagonist; Adenosine-5'-diphosphate, 2-[(3-aminopropyl)thio]-; 2-ATP-S-CH2CH2CH2NH2
EINECS	Contact for details

Quality Control

Our 2-((3-Aminopropyl)Thio)Adenosine 5'-Diphosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.