Description

1,2-(Oleoyl)-n-(6-((7-Nitrobenz-2-Oxa-1,3-Diazo-4-Yl)Aminocaproyl))Phosphatidylinositol is a highly specialized, fluorescently labeled derivative of phosphatidylinositol, a critical phospholipid in cellular signaling pathways. This compound is engineered for advanced research applications, offering a powerful tool for the visualization and study of lipid dynamics and protein-lipid interactions in biological membranes. It is primarily utilized by researchers in biochemistry, cell biology, and pharmacology for fluorescence microscopy, membrane trafficking studies, and the development of diagnostic assays.

Application

• Fluorescent Labeling of Phosphatidylinositols: Acts as a critical probe for tracking the localization and movement of phosphatidylinositol lipids within live or fixed cells using fluorescence microscopy.
• Membrane Biophysics Research: Used to study lipid bilayer properties, membrane fluidity, and the formation of lipid microdomains (e.g., lipid rafts).
• Protein-Lipid Interaction Studies: Essential for investigating the binding and activity of proteins that interact with phosphatidylinositol, such as kinases, phosphatases, and PH domains.
• Intracellular Signaling Pathway Analysis: Serves as a tracer to visualize and quantify changes in phosphoinositide levels during cellular signaling events.
• Development of Diagnostic & Screening Assays: Can be incorporated into in vitro assays to detect or measure enzymatic activity related to lipid metabolism.
• Liposome & Drug Delivery System Formulation: Used as a fluorescent marker to monitor the stability, targeting, and cellular uptake of engineered liposomal carriers.

Basic Information

Product Name	1,2-(Oleoyl)-n-(6-((7-Nitrobenz-2-Oxa-1,3-Diazo-4-Yl)Aminocaproyl))Phosphatidylinositol
CAS No.	110121-15-8
Molecular Formula	C58H94N5O17P
Molecular Weight	1164.4 g/mol
Synonyms	NBD-C6-PtdIns; NBD-PI; 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol) (NBD-C6 Amide); N-(6-((7-Nitro-2,1,3-benzoxadiazol-4-yl)amino)hexanoyl)-1,2-dioleoyl-sn-glycero-3-phosphoinositol; Fluorescent Phosphatidylinositol; NBD-C6-PI; 1,2-Dioleoyl Phosphatidylinositol-NBD; PI-NBD
EINECS	Contact for details

Quality Control

Our production of 1,2-(Oleoyl)-n-(6-((7-Nitrobenz-2-Oxa-1,3-Diazo-4-Yl)Aminocaproyl))Phosphatidylinositol adheres to stringent quality protocols to ensure batch-to-batch consistency and high performance in sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, mass spectrometry, and NMR to confirm identity, purity, and fluorescent labeling efficiency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, DMSO
Fluorescence Properties	Excitation ~465 nm, Emission ~535 nm (in methanol)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.