Description

Kifunensine CAS NO 109944-15-2 is a potent and highly selective inhibitor of the enzyme α-mannosidase I. This compound is a critical research tool for studying N-linked glycan processing in the endoplasmic reticulum, enabling the production of high-mannose type glycoproteins. It is essential for scientists in pharmaceutical R&D, biotechnology, and academic research focused on glycobiology, protein engineering, and the development of therapeutic biologics.

Application

• Glycobiology Research: A fundamental tool for inhibiting N-linked oligosaccharide processing to study glycan structure and function.
• Therapeutic Protein Production: Used in cell culture to produce recombinant proteins with high-mannose glycans, which can enhance antibody-dependent cellular cytotoxicity (ADCC) for monoclonal antibodies.
• Enzyme Mechanism Studies: Serves as a specific inhibitor to elucidate the catalytic mechanism and biological role of Class I α-mannosidases.
• Virology Research: Applied in studies of viral envelope glycoprotein maturation, affecting infectivity and immune evasion for viruses like HIV and influenza.
• Drug Discovery: Used in screening assays and target validation for diseases where glycosylation pathways are implicated, such as cancer and congenital disorders of glycosylation (CDGs).
• Cell Line Engineering: Aids in the development and characterization of glycoengineered cell lines for optimized biopharmaceutical production.

Basic Information

Product Name	Kifunensine
CAS No.	109944-15-2
Molecular Formula	C8H12N4O4
Molecular Weight	228.20 g/mol
Synonyms	(2R,3R,4R,5S)-2,3,4,5-Tetrahydroxy-2-(hydroxymethyl)piperidine-3,4,5-triol; Kifunensine; Mannostatin A; α-Mannosidase I Inhibitor; FR900494; (3R,4R,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)piperidine-2-one
EINECS	Contact for details

Quality Control

Our Kifunensine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.