Description

Succinimidyl-6-(Bromoacetamido)Caproate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive bromoacetamide group. This compound matters for its critical role in creating stable, covalent linkages between proteins, peptides, and other biomolecules, enabling advanced bioconjugation strategies. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, antibody-drug conjugate (ADC) production, and diagnostic assay kit formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For site-specific conjugation of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Protein and Peptide Labeling: Introduction of fluorescent dyes, biotin, or other probes onto thiol-containing biomolecules.
• Immobilization of Biomolecules: Covalent attachment of proteins or peptides to solid supports (e.g., beads, biosensor chips) for assay development.
• Crosslinking for Structural Studies: Investigation of protein-protein interactions and complex structures in structural biology.
• Oligonucleotide Conjugation: Modification of nucleic acids with proteins or other functional groups.
• Polymer Functionalization: Crafting functional polymers for drug delivery systems or biomaterials.

Basic Information

Product Name	Succinimidyl-6-(Bromoacetamido)Caproate
CAS No.	109880-16-2
Molecular Formula	C13H19BrN2O5
Molecular Weight	363.21 g/mol
Synonyms	N-Succinimidyl 6-((Bromoacetyl)amino)hexanoate; 6-((Bromoacetyl)amino)hexanoic Acid N-Hydroxysuccinimide Ester; Bromoacetamido-Caproate-OSu; S-BAC; NHS-Bromoacetamide-C6; N-6-(Bromoacetamido)caproyloxysuccinimide; (Bromoacetamido)caproic Acid NHS Ester; Bromoacetyl-C6-NHS Ester
EINECS	Contact for details

Quality Control

Our Succinimidyl-6-(Bromoacetamido)Caproate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.