Description

2-Formylphenyl Guanosine Monophosphate Ester is a chemically modified nucleotide derivative, specifically a guanosine monophosphate (GMP) esterified with a 2-formylphenyl group. This modification is critical for introducing reactive aldehyde functionality into oligonucleotide structures, enabling advanced bioconjugation and cross-linking applications. It is primarily utilized by research scientists and manufacturers in the fields of nucleic acid chemistry, oligonucleotide synthesis, and biopharmaceutical development for creating labeled probes, therapeutic conjugates, and novel biomaterials.

Application

• Oligonucleotide Labeling and Modification: Acts as a key intermediate for site-specific introduction of aldehyde groups into DNA or RNA strands for subsequent attachment of fluorophores, haptens, or other functional molecules.
• Bioconjugation Chemistry: The reactive aldehyde moiety enables stable conjugation with amines via Schiff base formation, useful for linking oligonucleotides to proteins, peptides, or solid surfaces.
• Cross-linking Agent in Structural Biology: Used in studies to probe nucleic acid-protein interactions or to create covalent cross-links for structural stabilization and analysis.
• Antisense and siRNA Therapeutic Development: Serves as a building block for synthesizing modified oligonucleotides with enhanced stability, targeting, or delivery properties for therapeutic applications.
• Diagnostic Probe Synthesis: Essential for manufacturing high-sensitivity probes used in fluorescence in situ hybridization (FISH), microarray assays, and other molecular diagnostics.
• Material Science: Used in the development of nucleic acid-based nanomaterials and hydrogels where controlled chemical linkage is required.

Basic Information

Product Name	2-Formylphenyl Guanosine Monophosphate Ester
CAS No.	109606-33-9
Molecular Formula	C17H18N5O9P
Molecular Weight	491.33 g/mol
Synonyms	2-Formylphenyl GMP Ester; Guanosine 5'-(2-formylphenyl phosphate); 5'-O-[Hydroxy(2-formylphenoxy)phosphoryl]guanosine; 2-Carboxybenzaldehyde Guanosine Monophosphate Ester; GMP-2-formylphenyl Ester; 2-Formylphenyl ester of guanosine monophosphate; 2-Formylbenzyl Guanosine Monophosphate (common misnomer); Reactive GMP Aldehyde Derivative
EINECS	Contact for details

Quality Control

Our production of 2-Formylphenyl Guanosine Monophosphate Ester adheres to stringent quality protocols suitable for research and development applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the integrity of the reactive aldehyde group. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data upon request, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed container with silica gel) due to its hygroscopic (moisture-sensitive) nature. For long-term storage, consider storing under an inert atmosphere to maintain the reactivity of the aldehyde group. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.