Description

Leucinostatin H CAS NO 109539-58-4 is a potent, non-ribosomal peptide antibiotic belonging to the leucinostatin family, characterized by its complex structure and significant biological activity. This compound is valued for its strong antifungal and cytotoxic properties, making it a critical tool in biochemical research and a candidate for therapeutic development. It is primarily sought by researchers and developers in the pharmaceutical, biotechnology, and agrochemical sectors for investigating novel antimicrobial agents and studying cell biology mechanisms.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of mitochondrial function, ATP synthesis inhibition, and ionophore activity.
• Antifungal Development: Serves as a lead compound in the research and development of new antifungal pharmaceuticals targeting resistant pathogens.
• Cell Biology Studies: Employed to investigate apoptosis (programmed cell death) and cytotoxicity in various cancer cell lines.
• Agricultural Research: Explored for potential use as a bio-fungicide or as a template for developing novel crop protection agents.
• Microbiology: Used in antimicrobial susceptibility testing and mechanism-of-action studies against a broad spectrum of fungi and some bacteria.
• Pharmaceutical Intermediates: May serve as a sophisticated intermediate or precursor in the synthesis of more complex therapeutic peptides.

Basic Information

Product Name	Leucinostatin H
CAS No.	109539-58-4
Molecular Formula	C₆₆H₁₁₃N₁₃O₁₅
Molecular Weight	1352.66 g/mol
Synonyms	Leucinostatin H; Antibiotic LL-AC541; Leucinostatin H (Antibiotic); LL-AC 541; LL-AC541; Leucinostatin H Antibiotic; Leucinostatin H Peptide; (2S)-2-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-Amino-3-methylbutanamido]-3-phenylpropanamido]-3-hydroxypropanamido]-4-methylpentanamido]-3-hydroxypropanamido]-3-(1H-imidazol-5-yl)propanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]-3-hydroxybutanamido]-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our Leucinostatin H is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 1.0%
Biological Activity	Assayed; Data on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.