Description

Dmt-Du-Ce Phosphoramidite is a high-purity, specialized phosphoramidite monomer used in oligonucleotide synthesis. This compound is critical for the automated solid-phase synthesis of DNA and RNA sequences, enabling precise control over genetic material assembly. It is an essential raw material for pharmaceutical R&D, diagnostic kit manufacturing, and academic research in molecular biology and genomics.

Application

• Oligonucleotide Synthesis: As a key building block in automated solid-phase synthesis for research-scale and therapeutic oligonucleotide production.
• Antisense & siRNA Therapeutics: For the manufacture of active pharmaceutical ingredients (APIs) used in gene silencing and targeted therapeutic applications.
• Diagnostic Probe Development: Used to synthesize labeled probes for PCR, microarrays, fluorescence in situ hybridization (FISH), and other molecular diagnostic techniques.
• Academic & Industrial Research: Enables the creation of custom DNA/RNA sequences for functional genomics, target validation, and biochemical studies.
• CRISPR Guide RNA Synthesis: A component in the synthesis of guide RNAs (gRNAs) for genome editing technologies.
• Aptamer Development: For the production of synthetic nucleic acid aptamers used in biosensing and targeted drug delivery systems.

Basic Information

Item	Details
Product Name	Dmt-Du-Ce Phosphoramidite
CAS No.	109389-30-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; DMT-dU-CE Phosphoramidite; 2'-Deoxyuridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; dU-CE Phosphoramidite (DMT); DMT-2'-Deoxyuridine-3'-CE Phosphoramidite; 5'-DMT-2'-deoxyuridine, 3'-(2-cyanoethyl diisopropylphosphoramidite)
EINECS	Contact for details

Quality Control

Our Dmt-Du-Ce Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and 31P NMR for structural confirmation, to meet the stringent requirements of pharmaceutical and diagnostic development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms
Identification (31P NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Moisture (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.