Description

Boc-Leu-Arg-Arg-Amc . 2 Hcl is a specialized, high-purity fluorogenic peptide substrate designed for sensitive protease activity assays. This compound is critical for biochemical research and pharmaceutical development, providing a reliable tool for the study of enzyme kinetics and inhibitor screening. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in proteomics and drug discovery.

Application

• Protease Activity Assays: As a fluorogenic substrate for trypsin-like serine proteases, including furin and related proprotein convertases.
• Biochemical Research: Used in kinetic studies to determine enzyme activity, specificity, and inhibition constants (Ki).
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors.
• Diagnostic Development: A key component in the development of fluorometric diagnostic tests for enzymatic pathways.
• Cell Biology Studies: Applied in cellular assays to monitor protease activation and function in biological processes.

Basic Information

Product Name	Boc-Leu-Arg-Arg-Amc . 2 Hcl
CAS No.	109358-46-5
Molecular Formula	C31H58Cl2N12O7
Molecular Weight	773.78 g/mol
Synonyms	Boc-Leu-Arg-Arg-7-amido-4-methylcoumarin dihydrochloride; t-Butyloxycarbonyl-Leucyl-Arginyl-Arginyl-4-Methylcoumaryl-7-Amide dihydrochloride; Boc-Leu-Arg-Arg-AMC; Boc-L-R-R-AMC·2HCl; Furin Substrate; Fluorogenic Peptide Substrate for Furin; Proprotein Convertase Substrate; 7-Amido-4-methylcoumarin (AMC) Peptide Substrate
EINECS	Contact for details

Quality Control

Every batch of Boc-Leu-Arg-Arg-Amc . 2 Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and in-vitro diagnostic use. A detailed Certificate of Analysis (COA), providing data on purity, identity, and impurity profiles, is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.