Description

D-Lys(Z)-Pro-Arg-Pna (Diacetate) is a synthetic peptide derivative, specifically a chromogenic substrate designed for enzymatic activity studies. This compound is of significant value in biochemical research and pharmaceutical development for its role in the precise detection and quantification of specific protease enzymes. It is primarily needed by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in enzymology, coagulation studies, and drug discovery processes.

Application

• Protease Enzyme Assays: Used as a selective chromogenic substrate for the kinetic study and activity measurement of specific serine proteases, including thrombin and related enzymes.
• Coagulation Research: Essential in hematology research for investigating blood coagulation pathways and screening for anticoagulant compounds.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel enzyme inhibitors for therapeutic development.
• Diagnostic Development: Serves as a key component in the formulation of in-vitro diagnostic (IVD) kits for clinical testing of coagulation disorders.
• Biochemical Research: A critical tool for academic and industrial researchers studying enzyme kinetics, specificity, and mechanism of action.
• Quality Control: Used in biopharmaceutical manufacturing for the potency testing of enzyme-based therapeutics.

Basic Information

Product Name	D-Lys(Z)-Pro-Arg-Pna (Diacetate)
CAS No.	108963-70-8
Molecular Formula	C35H50N10O9 • 2C2H4O2
Molecular Weight	Contact for details
Synonyms	D-Lys(Z)-Pro-Arg-pNA Diacetate; H-D-Lys(Z)-Pro-Arg-pNA • 2AcOH; Chromogenic Substrate for Thrombin; Benzyloxycarbonyl-D-lysyl-prolyl-arginyl-4-nitroanilide diacetate; Z-D-Lys-Pro-Arg-pNA diacetate; Thrombin Substrate I; Tosyl-Gly-Pro-Arg-p-nitroanilide acetate salt (related); S-2238 (related chromogenic substrate); p-Nitroanilide peptide substrate.
EINECS	Contact for details

Quality Control

Our D-Lys(Z)-Pro-Arg-Pna (Diacetate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing purity, assay, and related substance profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.