Description

D-Lys(Z)-Pro-Arg-Pna is a synthetic peptide substrate specifically designed for biochemical and pharmaceutical research. This compound is a critical tool for studying enzyme kinetics and inhibition, particularly in the context of proteolytic activity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for high-throughput screening and assay development.

Application

• Enzyme Substrate for Protease Research: Used as a chromogenic or fluorogenic substrate to measure the activity of specific proteases like thrombin, trypsin, and other serine proteases.
• Pharmaceutical Development: Employed in drug discovery programs for screening and characterizing potential protease inhibitors as therapeutic candidates.
• Biochemical Assay Kits: A key component in commercial and in-house diagnostic or research kits for quantifying protease activity in biological samples.
• Quality Control in Biologics: Used to monitor and validate the activity and purity of enzyme preparations in manufacturing processes.
• Academic & Institutional Research: Fundamental tool for investigating enzyme mechanisms, substrate specificity, and catalytic pathways in university and government laboratories.

Basic Information

Product Name	D-Lys(Z)-Pro-Arg-Pna
CAS No.	108963-69-5
Molecular Formula	C33H45N9O8
Molecular Weight	695.77 g/mol
Synonyms	D-Lys(Z)-Pro-Arg-p-Nitroanilide; H-D-Lys(Z)-Pro-Arg-pNA; D-Lysine, N2-[(phenylmethoxy)carbonyl]-, 1-[1-[4-(aminocarbonyl)phenyl]amino]-1-oxo-5-(4-nitrophenyl)-L-arginyl]prolyl-; Thrombin Substrate I (D-isomer); Boc-D-Lys(Z)-Pro-Arg-pNA; Chromogenic Substrate for Thrombin; Protease Substrate 108963-69-5; p-Nitroanilide Peptide Substrate
EINECS	Contact for details

Quality Control

Our D-Lys(Z)-Pro-Arg-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and spectrophotometric methods for functional activity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Spectrophotometric)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.