Description

Suc-Ala-Ala-Pro-Glu-Pna CAS NO 108929-37-9 is a synthetic peptide substrate specifically designed for enzymatic research and assay development. This compound is of critical importance for studying and quantifying the activity of proteolytic enzymes, particularly elastase and related serine proteases. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reliable substrates for kinetic studies and inhibitor screening.

Application

• Enzyme Activity Assays: Primary substrate for the spectrophotometric determination of human leukocyte elastase (HLE) and porcine pancreatic elastase activity.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate novel elastase inhibitors for therapeutic development in conditions like chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
• Biochemical Research: A key reagent in mechanistic studies of protease specificity, kinetics (Km, Vmax, kcat), and catalytic function.
• Diagnostic Kit Development: Incorporated into in-vitro diagnostic (IVD) kits for the detection of elastase levels in clinical samples.
• Quality Control in Biologics: Employed in QC labs to monitor the presence and activity of proteases during the manufacturing and purification of biopharmaceuticals.
• Academic Research: Fundamental tool in university and institutional labs for teaching and advanced research in enzymology and protein biochemistry.

Basic Information

Product Name	Suc-Ala-Ala-Pro-Glu-Pna
CAS No.	108929-37-9
Molecular Formula	C27H36N6O10
Molecular Weight	604.61 g/mol
Synonyms	N-Succinyl-Ala-Ala-Pro-Glu-p-nitroanilide; Suc-AAPG-pNA; Elastase Substrate IV; N-Succinyl-Alanyl-Alanyl-Prolyl-Glutamic Acid p-Nitroanilide; Suc-AAPF-pNA analog; Sucinyl-Ala-Ala-Pro-Glu-pNA; Protease Substrate S-2484 (related); AAPG-pNA
EINECS	Contact for details

Quality Control

Our Suc-Ala-Ala-Pro-Glu-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive enzymatic assays. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to guarantee batch-to-batch consistency and research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Assay	≥ 95.0% (on dried basis)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Specific Optical Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.