Description

(n-(4-Amino-4-Deoxy-N(10)-Methylpteroyl)Amino)-3-Chloro-4,5-Dihydro-5-Isoxazoleacetic Acid is a high-purity, non-natural folate analog with significant biochemical research and pharmaceutical development potential. Its value lies in its specific structural modifications, which make it a critical intermediate for synthesizing targeted therapeutic agents and biochemical probes. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focused on oncology, metabolic disease research, and advanced drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antifolate drugs and targeted cancer therapeutics.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies related to folate metabolism and one-carbon transfer pathways.
• Anticancer Agent Development: Serves as a core structure for developing compounds that target dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Proteomics & Molecular Biology: Utilized in the design of chemical probes for studying protein function and cellular signaling networks.
• Academic & Institutional Research: Fundamental material for investigating novel mechanisms of action and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	(n-(4-Amino-4-Deoxy-N(10)-Methylpteroyl)Amino)-3-Chloro-4,5-Dihydro-5-Isoxazoleacetic Acid
CAS No.	108743-20-0
Molecular Formula	C15H16ClN7O4
Molecular Weight	393.78 g/mol
Synonyms	3-Chloro-4,5-dihydro-5-isoxazoleacetic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-; AG 2034; NSC 654663; Isoxazoleacetic acid folate analog; N-(4-(N-((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)methylamino)benzoyl)-3-chloro-4,5-dihydro-5-isoxazoleacetic acid; Glycinamide, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-3-chloro-4,5-dihydro-5-isoxazole-; Antifolate AG2034
EINECS	Contact for details

Quality Control

Our (n-(4-Amino-4-Deoxy-N(10)-Methylpteroyl)Amino)-3-Chloro-4,5-Dihydro-5-Isoxazoleacetic Acid is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.