Description

N6-Monobutyryl-2'-Deoxyadenosine 3':5'-Cyclic Monophosphate Sodium Salt is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), designed for enhanced cell membrane permeability and resistance to phosphodiesterase degradation. This compound serves as a potent and stable analog of the crucial second messenger cAMP, enabling precise research into intracellular signaling pathways. It is primarily utilized by researchers in pharmaceutical development, biochemistry, and molecular biology for studying protein kinase A (PKA) activation, gene expression regulation, and cellular response mechanisms.

Application

• Biochemical Research: As a cell-permeable cAMP analog to activate Protein Kinase A (PKA) and study downstream signaling cascades in cell culture models.
• Pharmaceutical Screening: Used in high-throughput assays to identify and evaluate novel phosphodiesterase (PDE) inhibitors or modulators of cAMP-dependent pathways.
• Cardiovascular & Metabolic Studies: Investigation of cAMP's role in cardiac function, vascular tone, and metabolic regulation using a more stable agonist.
• Neuroscience Research: Probing the effects of cAMP signaling on neuronal plasticity, neurotransmitter release, and long-term potentiation (LTP).
• Cell Biology: Studying the impact of sustained cAMP elevation on cell proliferation, differentiation, and apoptosis.
• Enzymology: Serving as a substrate or effector in enzymatic studies related to adenylate cyclase or phosphodiesterase activity.

Basic Information

Product Name	N6-Monobutyryl-2'-Deoxyadenosine 3':5'-Cyclic Monophosphate Sodium Salt
CAS No.	108347-96-2
Molecular Formula	C18H22N5O7P • Na
Molecular Weight	474.36 g/mol
Synonyms	N6-Butyryl-cAMP-dA; N6-Butyryl-2'-deoxyadenosine-3',5'-cyclic monophosphate sodium salt; db-cAMP-dA Sodium Salt; N6-Monobutyryl-2'-deoxy-cAMP Sodium Salt; 2'-Deoxy-N6-butyryladenosine-3',5'-cyclic monophosphate sodium salt; Butyryl-deoxy-cAMP; N6-Butyryl-2'-deoxy-cAMP Na+
EINECS	Contact for details

Quality Control

Our N6-Monobutyryl-2'-Deoxyadenosine 3':5'-Cyclic Monophosphate Sodium Salt is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, with testing performed via HPLC, NMR, and mass spectrometry to confirm chemical structure and meet specified purity criteria.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.