Description

1,2-Dioctadecanoyl-Sn-Glycero-3-Phospho-Rac-[1-Glycerol] Ammonium Salt is a high-purity synthetic phospholipid, specifically a saturated phosphatidylglycerol (PG) derivative. This compound is critical for creating stable, well-defined lipid bilayers and vesicles, serving as a fundamental building block in advanced biomimetic research and formulation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors who require precise control over membrane properties for drug delivery systems, diagnostic assays, and model membrane studies.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key structural component for creating stable, anionic liposomal carriers for drug and gene delivery (e.g., mRNA vaccines, anticancer therapeutics).
• Biomimetic Membrane Models: Used in the construction of supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs) for biophysical studies of membrane-protein interactions and permeability.
• Pulmonary Surfactant Research: Serves as a synthetic analog in studies investigating lung surfactant function and for developing therapeutic surfactant replacements.
• Diagnostic Reagent Preparation: Employed in the development of diagnostic kits and biosensors where a stable, functionalized lipid interface is required.
• Cell Culture & Cryopreservation: Acts as a protective agent in specialized cell culture media and cryoprotectant formulations.
• Cosmetic & Dermal Delivery Systems: Incorporated into high-end cosmetic formulations like nanosomes and niosomes for enhanced skin penetration and stabilization of active ingredients.

Basic Information

Product Name	1,2-Dioctadecanoyl-Sn-Glycero-3-Phospho-Rac-[1-Glycerol] Ammonium Salt
CAS No.	108347-80-4
Molecular Formula	C42H86NO10P
Molecular Weight	795.11 g/mol
Synonyms	1,2-Distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt); DSPG; PG(18:0/18:0); Phosphatidylglycerol (18:0); 1,2-Distearoylphosphatidylglycerol; DSPG-Na; 1,2-Di-O-octadecanoyl-rac-glycero-3-phospho-(1'-glycerol); Distearoylphosphatidylglycerol
EINECS	Contact for details

Quality Control

Our 1,2-Dioctadecanoyl-Sn-Glycero-3-Phospho-Rac-[1-Glycerol] Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, NMR for structural confirmation, and mass spectrometry, to ensure it meets the stringent requirements for research and cGMP-guided formulation development. A detailed Certificate of Analysis (COA) documenting identity, purity, and critical impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Phase Transition Temperature (DSC)	Approx. 55°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.