Description

D-Myo-Inositol 1,4,5-Trisphosphate Hexasodium Salt is a high-purity, cell-permeant salt form of the critical second messenger IP3 (Inositol 1,4,5-trisphosphate). This compound is essential for studying intracellular calcium signaling pathways, as it directly triggers the release of calcium ions from endoplasmic reticulum stores. It is a fundamental research tool for scientists in pharmacology, neuroscience, cell biology, and biochemistry investigating receptor-mediated signal transduction, cellular communication, and related disease mechanisms.

Application

• Intracellular Calcium Signaling Research: Used as a standard tool to induce and study calcium release in permeabilized cells, cell lysates, and microsomal preparations.
• Pharmacological Assay Development: Serves as a key agonist in high-throughput screening (HTS) assays to identify modulators of IP3 receptors and related signaling pathways.
• Neuroscience Studies: Applied in research on synaptic plasticity, neuronal excitability, and neurotransmitter release mechanisms where IP3-mediated calcium signaling plays a central role.
• Cell Physiology Investigations: Utilized to probe the role of calcium in processes such as muscle contraction, fertilization, gene transcription, and apoptosis.
• Enzyme Substrate: Acts as a substrate for enzymes like inositol polyphosphate phosphatases and kinases in enzymatic activity studies.
• Diagnostic Kit Component: May be incorporated into specialized diagnostic or research kits for measuring IP3 receptor activity or cellular calcium flux.

Basic Information

Item	Detail
Product Name	D-Myo-Inositol 1,4,5-Trisphosphate Hexasodium Salt
CAS No.	108340-81-4
Molecular Formula	C6H9Na6O15P3
Molecular Weight	660.03 g/mol
Synonyms	IP3 Hexasodium Salt; Inositol 1,4,5-Trisphosphate Hexasodium Salt; D-myo-Inositol 1,4,5-trisphosphate, hexasodium salt; 1D-myo-Inositol 1,4,5-trisphosphate hexasodium salt; Ins(1,4,5)P3 Hexasodium; Inositol-1,4,5-trisphosphate hexasodium salt; D-Ins(1,4,5)P3, Hexasodium Salt
EINECS	Contact for details

Quality Control

Our D-Myo-Inositol 1,4,5-Trisphosphate Hexasodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and identity verification. A detailed Certificate of Analysis (COA) providing purity, assay, and impurity profile is supplied with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 97%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.