Description

4-Thiouridine 5'-Diphosphate Ammonium is a modified nucleotide derivative where the oxygen atom at the 4-position of the uracil ring is replaced by sulfur. This compound is a critical biochemical reagent, serving as a substrate or precursor in enzymatic studies and nucleic acid research. It is essential for researchers and manufacturers in the fields of molecular biology, enzymology, and pharmaceutical development, particularly for investigating RNA metabolism, synthesizing labeled probes, and developing novel therapeutic agents.

Application

• Enzymatic Substrate: Used as a specific substrate for studying the activity and kinetics of RNA-modifying enzymes, such as kinases and polymerases.
• Biochemical Research: A key reagent in the synthesis of thio-labeled RNA oligonucleotides for structural studies and functional assays.
• Pharmaceutical Development: Acts as a precursor in the research and development of nucleotide-based therapeutics and diagnostic tools.
• Metabolic Pathway Analysis: Employed in tracing and understanding nucleotide salvage pathways and RNA turnover mechanisms.
• Cross-linking Studies: Utilized in photo-cross-linking experiments due to the unique reactivity of the thione group in RNA-protein interaction studies.

Basic Information

Product Name	4-Thiouridine 5'-Diphosphate Ammonium
CAS No.	108322-05-0
Molecular Formula	C9H17N3O13P2S · xNH3
Molecular Weight	Contact for details
Synonyms	4-Thio-UDP Ammonium Salt; 4sUDP Ammonium; 4-Thiouridine diphosphate ammonium salt; UDP-4-thio ammonium; 4-Thiouridine 5'-(trihydrogen diphosphate) ammonium salt; 4-Thio-uridine-5'-diphosphate ammonium; 4-Thiouridine 5'-pyrophosphate ammonium
EINECS	Contact for details

Quality Control

Our 4-Thiouridine 5'-Diphosphate Ammonium is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.