Description

2'-Amino-2'-Deoxyguanosine-5'-Triphosphate Tetralithium Salt is a chemically modified nucleotide triphosphate analog, a critical building block for advanced biochemical research and development. Its primary value lies in its ability to act as a chain terminator or substrate analog in enzymatic studies, particularly for investigating DNA/RNA polymerase mechanisms and nucleic acid metabolism. This high-purity biochemical is essential for researchers and developers in the fields of molecular biology, enzymology, and next-generation sequencing technology development.

Application

• Molecular Biology Research: Used as a specialized substrate or inhibitor in studies of DNA and RNA polymerases to understand replication fidelity and enzyme kinetics.
• Next-Generation Sequencing (NGS): Serves as a key reagent in the development of novel sequencing-by-synthesis (SBS) platforms and other advanced genomic analysis techniques.
• Enzymology Studies: Employed to probe the active sites and catalytic mechanisms of nucleic acid-processing enzymes, including reverse transcriptases and telomerase.
• Antiviral & Anticancer Drug Discovery: Acts as a precursor or model compound in the research and development of nucleotide analog-based therapeutics targeting viral polymerases or cellular replication.
• Biochemical Assay Development: Utilized in creating high-sensitivity diagnostic assays and functional tests for enzyme activity and inhibition.
• Synthetic Biology: Provides a modified nucleotide for the engineering of novel enzymatic pathways or the synthesis of modified nucleic acids with unique properties.

Basic Information

Product Name	2'-Amino-2'-Deoxyguanosine-5'-Triphosphate Tetralithium Salt
CAS No.	108269-13-2
Molecular Formula	C10H13Li4N6O13P3
Molecular Weight	Approx. 574.04 g/mol (Lithium salt form)
Synonyms	2'-NH2-dGTP (Tetralithium Salt); 2'-Amino-2'-deoxy-GTP; 2'-Amino-dGTP; 2'-Amino-2'-deoxyguanosine-5'-(tetrahydrogen triphosphate), tetralithium salt; dGTP-2'-NH2; 2'-Deoxy-2'-aminoguanosine-5'-triphosphate tetralithium salt; GTP analog, 2'-amino modified; 2'-Amino-2'-deoxyguanosine triphosphate Li salt
EINECS	Contact for details

Quality Control

This high-grade biochemical is produced under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Quality is verified by multiple orthogonal analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities such as nucleases or phosphatase activity. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and specific impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
pH (in solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg (if specified for biological use)
Biological Activity	Tested in appropriate enzyme assay (e.g., polymerase incorporation)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.