Description

n-Acetylgalactosamine-Dextran Conjugate is a specialized biochemical reagent designed for targeted drug delivery and cellular research applications. This conjugate is engineered to leverage the specific binding affinity of N-acetylgalactosamine (GalNAc) to asialoglycoprotein receptors (ASGPR) on hepatocytes, making it a critical tool for liver-targeted therapies. It is essential for researchers and developers in the pharmaceutical and biotechnology sectors working on advanced therapeutics, diagnostics, and glycobiology studies. The product is supplied as a high-purity, well-characterized material to ensure consistent performance in sensitive biological assays.

Application

• Targeted Drug Delivery Systems: Serves as a carrier or targeting ligand for liver-specific delivery of therapeutic agents, including siRNA, mRNA, and small molecule drugs.
• Glycobiology Research: Used as a model compound to study carbohydrate-protein interactions, receptor-mediated endocytosis, and cellular uptake mechanisms.
• Diagnostic Probe Development: Acts as a scaffold for developing imaging agents and diagnostic probes targeted to hepatic tissues.
• Vaccine Adjuvant Research: Explored as a potential immunomodulatory carrier to enhance antigen presentation and immune response.
• Bioconjugation & Surface Modification: Utilized for modifying nanoparticles, liposomes, or other surfaces to impart hepatocyte-targeting capabilities.
• In Vitro & In Vivo Studies: Applied in both cell culture and animal models to validate targeting efficiency and biodistribution.

Basic Information

Product Name	n-Acetylgalactosamine-Dextran Conjugate
CAS No.	107902-98-7
Molecular Formula	Typically a complex biopolymer conjugate; contact for specific formula based on dextran chain length and substitution ratio.
Molecular Weight	Variable, depending on dextran molecular weight (e.g., 10kDa, 40kDa, 70kDa) and degree of GalNAc substitution.
Synonyms	GalNAc-Dextran Conjugate; Dextran-N-acetylgalactosamine Conjugate; N-Acetyl-D-galactosamine-dextran; ASGPR Targeting Ligand-Dextran; Hepatocyte-Targeting Dextran; GalNAc-Polyaccharide Conjugate; Dextran-GalNAc; D-GalNAc-dextran
EINECS	Contact for details.

Quality Control

Every batch of our n-Acetylgalactosamine-Dextran Conjugate is manufactured and tested under a strict quality management system. We ensure critical parameters such as degree of substitution, molecular weight distribution, endotoxin levels, and bioburden are controlled to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance is provided with each shipment to guarantee reproducibility and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake. For short-term use, aliquots may be stored at 2-8°C for up to one week.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (IR / NMR)	Conforms to structure
Dextran Backbone MW	10 kDa, 40 kDa, 70 kDa (or as specified)
Degree of Substitution (GalNAc/dextran)	10 - 50 mol% (or as specified)
Purity (HPLC / SEC)	≥ 95%
Endotoxin	< 10 EU/mg
Bioburden	To customer specification
Solubility	Soluble in water, PBS, and common aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.