Description

20-Hydroxy-n-Acetylleukotriene E4 is a specialized eicosanoid metabolite derived from leukotriene E4. This compound is of significant value as a critical reference standard and research biochemical for investigating inflammatory and immunological pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic kit manufacturers focused on respiratory diseases, allergy mechanisms, and lipid mediator biology.

Application

• Biomedical Research: Used as a high-purity reference standard in studies of leukotriene metabolism, inflammation, and asthma pathogenesis.
• Pharmaceutical Development: Serves as a key analytical standard in the discovery and validation of drugs targeting the 5-lipoxygenase pathway.
• Diagnostic Assays: Employed in the calibration and quality control of immunoassays (e.g., ELISA) designed to quantify leukotriene metabolites in biological samples.
• Metabolomics & Lipidomics: Acts as a critical identifier in mass spectrometry-based profiling of eicosanoids and oxylipins in clinical and preclinical samples.
• Academic Studies: Facilitates fundamental research into the role of cysteinyl leukotrienes in cellular signaling and disease models.

Basic Information

Product Name	20-Hydroxy-n-Acetylleukotriene E4
CAS No.	107701-63-3
Molecular Formula	C25H39NO8S
Molecular Weight	513.65 g/mol
Synonyms	20-Hydroxy-N-acetyl-LTE4; 20-Hydroxy-N-acetylleukotriene E4; 20-Hydroxy-N-acetyl-LTE4; 20-OH-N-Ac-LTE4; 20-Carboxy-N-acetylleukotriene E4; N-Acetyl-20-hydroxy-leukotriene E4; 5(S),6(R)-Epoxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid, 20-hydroxy-N-acetylcysteinyl-; LTE4 metabolite
EINECS	Contact for details

Quality Control

Our 20-Hydroxy-n-Acetylleukotriene E4 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and stability. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, methanol; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.