Description

1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phospho(Tempo)Choline is a specialized, spin-labeled phospholipid analog, a critical tool for advanced biophysical research. Its unique structure, incorporating a stable nitroxide radical (Tempo) into the phosphatidylcholine headgroup, enables non-perturbing investigation of membrane dynamics and structure. This compound is essential for researchers in biophysics, membrane biology, and pharmaceutical development who require precise probes for electron paramagnetic resonance (EPR) spectroscopy and fluorescence quenching studies.

Application

• Membrane Biophysics Research: As a spin probe for Electron Paramagnetic Resonance (EPR) spectroscopy to study lipid bilayer fluidity, phase transitions, and lateral organization.
• Lipid Vesicle & Liposome Characterization: Used to investigate the permeability, stability, and fusion properties of model membranes and drug delivery vesicles.
• Protein-Lipid Interaction Studies: Employed to map the interaction sites and depth of penetration of membrane-associated proteins and peptides within the lipid bilayer.
• Antioxidant Activity Studies: The Tempo moiety itself can serve as a model to study radical scavenging and oxidative processes within lipid environments.
• Fluorescence Quenching Reference: Acts as a efficient quencher for fluorescence-based assays to determine the location and accessibility of fluorophores in membranes.
• Development of Advanced Biomaterials: Used in the design and testing of synthetic membranes and lipid-based nanomaterials for diagnostic and therapeutic applications.

Basic Information

Product Name	1-Palmitoyl-2-Oleoyl-Sn-Glycero-3-Phospho(Tempo)Choline
CAS No.	107576-70-5
Molecular Formula	C₄₇H₉₃N₂O₈P
Molecular Weight	857.23 g/mol
Synonyms	POPC Tempo; 16:0-18:1 PC Tempo; 1-Palmitoyl-2-oleoyl-phosphatidylcholine Tempo; Tempo-POPC; POPC labeled with Tempo; Phosphatidylcholine, 1-palmitoyl-2-oleoyl-, 3-(Tempo) derivative; Nitroxide-labeled POPC; EPR probe lipid
EINECS	Contact for details

Quality Control

Our high-purity research-grade lipids are produced under stringent conditions to ensure batch-to-batch consistency and reliability for sensitive experiments. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Under these recommended conditions, the product is stable for at least two years. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.