Description

Nonanedioic Acid 1,9-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is a high-purity, bifunctional chemical linker featuring reactive pyrrolidinedione (succinimidyl) ester groups. This compound is critical for creating stable amide bonds with primary amines, enabling the synthesis of advanced polymers, cross-linked materials, and bioconjugates. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, polymer science, and specialty chemical industries for developing novel materials with tailored properties.

Application

• Polymer Cross-linking Agent: Used to introduce covalent cross-links in polymer chains, enhancing thermal stability, mechanical strength, and chemical resistance in specialty coatings, adhesives, and high-performance resins.
• Bioconjugation & Protein Modification: Serves as a homobifunctional linker for attaching peptides, proteins, or other biomolecules to surfaces, carriers, or diagnostic labels in biopharmaceutical development.
• Dendrimer & Macromolecule Synthesis: A key building block for constructing complex, well-defined dendritic structures and star-shaped polymers due to its symmetrical, reactive end groups.
• Surface Functionalization: Employed to modify material surfaces (e.g., nanoparticles, silicon wafers, polymers) with amine-reactive groups for subsequent immobilization of ligands or catalysts.
• Hydrogel Formation: Facilitates the creation of covalently cross-linked hydrogel networks for applications in drug delivery systems, tissue engineering scaffolds, and contact lenses.
• Analytical Reagent: Acts as a derivatization agent in analytical chemistry to modify compounds for enhanced detection via chromatography or mass spectrometry.

Basic Information

Product Name	Nonanedioic Acid 1,9-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	106664-96-4
Molecular Formula	C17H22N2O8
Molecular Weight	382.37 g/mol
Synonyms	1,9-Bis(2,5-dioxopyrrolidin-1-yl) nonanedioate; Azelaic Acid Bis(N-hydroxysuccinimide) Ester; Azelaic Acid Bis(NHS) Ester; Bis(N-succinimidyl) Azelate; NHS-Azelate-NHS; DISA; Nonanedioic Acid Bis(2,5-dioxo-1-pyrrolidinyl) Ester; Homobifunctional NHS Ester (C9)
EINECS	Contact for details

Quality Control

Our Nonanedioic Acid 1,9-Bis(2,5-Dioxo-1-Pyrrolidinyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.