Description

2-Desamino-5,8-Dideazafolic Acid is a key folate analog and synthetic intermediate of significant interest in pharmaceutical research and development. Its modified pteridine structure makes it a valuable scaffold for designing novel enzyme inhibitors and therapeutic agents. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of antifolate drugs and biochemical pathway studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antifolate chemotherapeutic agents and targeted therapies.
• Biochemical Research: Used as a reference standard or inhibitor in studies of folate-dependent enzymes, such as dihydrofolate reductase (DHFR) and thymidylate synthase.
• Medicinal Chemistry: Serves as a core structure for the design and development of new chemical entities with potential anticancer or antimicrobial activity.
• Academic Research: Employed in universities and research labs for investigating folate metabolism and related biochemical pathways.
• Process Development: Used in scaling up synthetic routes for complex pharmaceutical molecules within process chemistry departments.

Basic Information

Product Name	2-Desamino-5,8-Dideazafolic Acid
CAS No.	106585-70-0
Molecular Formula	C19H19N5O5
Molecular Weight	397.39 g/mol
Synonyms	5,8-Dideazafolic Acid, 2-Desamino-; 2-Desamino-5,8-dideazapteroylglutamic Acid; 2-Desamino-5,8-DDA Folic Acid; NSC 339531; 4-[[2-[[(2-Amino-4-oxo-5,6,7,8-tetrahydro-3-quinazolinyl)methyl]amino]benzoyl]amino]benzoic Acid; 2-Desamino-5,8-Dideazapteroyl-L-glutamic Acid; L-Glutamic acid, N-[4-[[(2-amino-5,6,7,8-tetrahydro-4-oxo-3-quinazolinyl)methyl]amino]benzoyl]-
EINECS	Contact for details

Quality Control

Our 2-Desamino-5,8-Dideazafolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.