Description

Lometrexol is a potent antifolate compound that acts as a selective inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a key enzyme in the de novo purine biosynthesis pathway. This targeted mechanism makes it a compound of significant interest for advanced research and development. It is primarily utilized by pharmaceutical researchers and developers investigating novel therapeutic strategies, particularly in the fields of oncology and metabolic disease.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anticancer agents.
• Biochemical Studies: Used as a selective tool compound to study the purine biosynthesis pathway, enzyme kinetics, and cellular folate metabolism in vitro.
• Oncology Research: Investigated for its potential antitumor activity in various cancer cell lines and preclinical models due to its inhibition of nucleotide synthesis.
• Metabolic Pathway Analysis: Employed in research to understand the role of GARFT in cell proliferation and to identify potential metabolic vulnerabilities.
• High-Purity Chemical Supply: Supplied to academic institutions, contract research organizations (CROs), and biotech companies for discovery-stage programs.

Basic Information

Product Name	Lometrexol
CAS No.	106400-81-1
Molecular Formula	C20H23N7O6
Molecular Weight	457.44 g/mol
Synonyms	6R-5,10-Dideazatetrahydrofolic acid; DDATHF; (6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid; LY264618; Lometrexol hydrate; 5,10-Dideazatetrahydrofolate; GARFT Inhibitor
EINECS	Contact for details

Quality Control

Our Lometrexol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity determination by HPLC. A detailed Certificate of Analysis (COA) documenting purity, related substances, and residual solvents is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.